REGILENT
Cell senescence, a distinctive feature of aging is a frequent consequence of cumulative DNA damage, epigenetic alterations and changes in the cell architecture. Senescent cells exhibit characteristic Senescence-Associated Secretory Phenotype (SASP) causing damage and inflammation of neighboring tissues.
Additionally, with age, stem cells accumulate huge amounts of DNA damage, when compared to somatic cells. This is expected trait, however, due to their longevity and replication ability. They can propagate these heritable mutations to progeny, leading to more pronounced senescence, inability to repair tissues and cancer – a major feature of aging process.
R-GEN project consists of development of small molecule that will prevent senescent stem cells formation while providing controlled apoptosis of senescent somatic cells. It includes a consolidation of activities that interfere cell damage factors and defective apoptotic signal. In the future, R-GEN may enable efficient tissue regeneration thus increasing longevity and reducing age related complications.